Health & Environmental Research Online (HERO)


Print Feedback Export to File
2725964 
Journal Article 
Review 
Drug-induced gynecomastia 
Hugues, FC; Gourlot, C; Le Jeunne, C 
2000 
Yes 
Annales de Medecine Interne
ISSN: 0003-410X 
151 
1 
10-17 
French 
10761558 
WOS:000086325200002 
Drugs are a very common cause of gynecomastia and should always be entertained as the possible causal agent of such a condition. This drug side-effect is due to an impaired balance in the serum estrogen/serum androgen ratio, whatever the mechanism, or a rise in prolactin level. Sex hormones, antiandrogens, are frequently involved as well as spironolactone, cimetidine, verapamil and cancer chemotherapy (especially alkylating agents). Diazepam, tricyclic antidepressants, neuroleptics, calcium channel blockers, captopril, digitalis glycosides, omeprazole, some antibiotics and growth hormone are all possibly, but less often, the responsible agent. Criteria of the French method for determining drug causality are discussed. 
gynecomastia; drug side-effects; drug causality