US EPA

2727135 

Journal Article 

Evaluation of the disintegration efficiency of a sodium starch glycolate prepared from enset starch in compressed tablets 

Gebre-Mariam, T; Winnemoller, M; Schmidt, PC 

1996 

1 

European Journal of Pharmaceutics and Biopharmaceutics
ISSN: 0939-6411
EISSN: 1873-3441 

IPA/96/1112200 

J 

REF 47 

124-132 

English 

IPA COPYRIGHT: ASHP The disintegration efficiency of a sodium starch glycolate (SSG) prepared from enset starch (SSG-E) was evaluated in alpha-lactose monohydrate (LM) and calcium phosphate dibasic dihydrate (dicalcium phosphate dihydrate; CPDD) tablets by comparing similar tablets containing sodium starch glycolate from potato starch (Primojel) or croscarmellose sodium (Ac-Di-Sol). For LM tablets, where disintegration mechanisms depended on swelling rates, and water uptake, SSG-E was more efficient than Primojel or Ac-Di-Sol. SSG-E tablets exhibited shorter disintegration times, faster swelling rates, and water uptake. In CPDD tablets, significant differences were not found in efficiency of SSGs. Where passive mechanisms were involved in disintegration, SSG-E and Primojel were more efficient than Ac-Di-Sol. Where active mechanisms prevailed, SSGs were less efficient. CPDD tablets prepared with Ac-Di-Sol showed faster disintegration times, swelling rates, and water uptake. Physicochemical studies on SSG-E and Primojel revealed similarity in viscosity and particle size, but differences in sedimentation volume, shape, and water soluble fractions.