Hepatocellular carcinoma with peritoneal dissemination which was regressed during vitamin K2 and vitamin E administration | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2727391

Reference Type

Journal Article

Title

Hepatocellular carcinoma with peritoneal dissemination which was regressed during vitamin K2 and vitamin E administration

Author(s)

Otsuka, T; Hagiwara, S; Tojima, H; Yoshida, H; Takahashi, T; Nagasaka, K; Tomioka, S; Ando, T; Takeuchi, K; Kori, T; Ohno, Y; Kakizaki, S; Takagi, H; Mori, M

Year

2007

Is Peer Reviewed?

Yes

Journal

Internal Medicine
ISSN: 0918-2918
EISSN: 1349-7235

Volume

Issue

Page Numbers

711-715

Language

English

PMID

17541221

DOI

10.2169/internalmedicine.46.6131

Web of Science Id

WOS:000258843500005

Abstract

A 65-year-old man with positive anti-hepatitis C antibody and chronic renal failure was diagnosed as having a ruptured hepatocellular carcinoma (HCC) based on computed tomography (CT). The patient underwent transcatheter arterial embolization (TAE) for the HCC. After one more session of TAE, the patient underwent surgery. But HCC seeding peritoneally was pointed out. Vitamin K2 and vitamin E were administered as a conservative treatment. Six months after starting vitamins K2 and E, the primary tumor did not increase in size and intraperitoneal dissemination disappeared on CT with a significant decrease of alpha-fetoprotein. Even though this is only one case, combination therapy of vitamin K2 and E may induce growth suppression of HCC.

Keywords

hepatocellular carcinoma; vitamin K2; vitamin E