Multicenter controlled trial of tienilic acid in hyperuricemic, hypertensive subjects, with intensive monitoring of liver function | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2727548

Reference Type

Journal Article

Title

Multicenter controlled trial of tienilic acid in hyperuricemic, hypertensive subjects, with intensive monitoring of liver function

Author(s)

Andrews, DI; Bailey, RR; Campbell, DG; Dickson, DSP; Kiddle, GB; Et al

Year

1983

Is Peer Reviewed?

Yes

Journal

British Journal of Clinical Pharmacology
ISSN: 0306-5251
EISSN: 1365-2125

Report Number

IPA/84/573026

Volume

Issue

REF 25

Page Numbers

513-518

Language

English

Abstract

IPA COPYRIGHT: ASHP Tienilic acid (ticrynafen; I) was evaluated in 96 patients; 50 were randomized to treatment with I and 47 to conventional diuretic therapy. The mean daily dose was 278 mg. Mean follow-up was 8.5 months. Mean liver function indices were not affected in either group of patients. The general incidence of side effects was low. Advantages of I in hyperuricemic hypertensive patients were noted.