Nicotinic acid effectiveness in the treatment of benzodiazepine withdrawal | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

2729121

Reference Type

Journal Article

Title

Nicotinic acid effectiveness in the treatment of benzodiazepine withdrawal

Author(s)

Vescovi, PP; Gerra, G; Ippolito, L; Caccavari, R; Passeri, M; Et al

Year

1987

Is Peer Reviewed?

Yes

Journal

Current Therapeutic Research
ISSN: 0011-393X

Report Number

IPA/88/792053

Volume

Ther

Issue

REF 20

Page Numbers

1017-1021

Language

English

Abstract

IPA COPYRIGHT: ASHP A randomized, placebo controlled study was conducted to evaluate the effectiveness of 0.75-3 g/day of intravenous xantinol nicotinate (xanthinol niacinate; Complamin; I) injection in decreasing the severity of benzodiazepine withdrawal in 28 flunitrazepam abusers at the dose of 8-10 mg/day. The group treated with I showed significantly lower frequency and severity of withdrawal symptoms than the group treated with placebo. The data suggest that nicotinic acid or nicotinamide may be considered endogenous ligands for benzodiazepine receptors in the human brain.