Health & Environmental Research Online (HERO)


Print Feedback Export to File
2729430 
Journal Article 
Ibopamine in congestive heart failure refractory to digitalis, diuretics, and captopril 
Marchionni, N; Conti, A; De Alfieri, W; Di Bari, M; Vannucci, A; Et al 
1986 
Yes 
Journal of Clinical Pharmacology
ISSN: 0091-2700
EISSN: 1552-4604 
IPA/86/690019 
Clin 
REF 6 
74-77 
English 
IPA COPYRIGHT: ASHP The efficacy of oral ibopamine (I) given in a dose of 1.25 mg/kg, was assessed in 6 patients (aged 48-67 yr) with congestive heart failure refractory to daily treatment with 0.125-0.250 mg digoxin (II), 25-250 mg furosemide (III), and 25 mg captopril (IV), 3-4 times a day; the patients were maintained on therapy with all 4 drugs and followed up for about 3 months. The hemodynamic improvement induced by I was relatively modest. The stroke index to mean pulmonary capillary wedge pressure ratio rose only from a basal level of 29% of the lower limit of normal to 32% at the time of effect of I. A greater enhancement to 39% of normal was gained with the addition of IV, suggesting some advantage in using vasodilators in conjunction with I to obtain more hemodynamic improvement and to prevent possible increase in pulmonary pressures. Five of 6 patients experienced increasing dyspnea after I dosing which disappeared on I discontinuation and evidence of liver toxicity was evident in one patient.