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Citation
Tags
HERO ID
2729894
Reference Type
Journal Article
Title
A phase II trial of temsirolimus in men with castration-resistant metastatic prostate cancer
Author(s)
Armstrong, AJ; Shen, T; Halabi, S; Kemeny, G; Bitting, RL; Kartcheske, P; Embree, E; Morris, K; Winters, C; Jaffe, T; Fleming, M; George, DJ
Year
2013
Is Peer Reviewed?
Yes
Journal
Clinical Genitourinary Cancer
ISSN:
1558-7673
EISSN:
1938-0682
Volume
11
Issue
4
Page Numbers
397-406
Language
English
PMID
23830964
DOI
10.1016/j.clgc.2013.05.007
Web of Science Id
WOS:000327139500011
Abstract
BACKGROUND:
Phosphatase and tensin homologue (PTEN) loss is common in advanced prostate cancer, leading to constitutive activation of the PI3 kinase pathway. Temsirolimus blocks mammalian target of rapamycin (mTOR)/target of rapamycin complex 1 (TORC1), a key signaling node in this pathway; its activity in men with advanced castration-resistant metastatic prostate cancer (mCRPC) is unknown.
METHODS:
We conducted a single-arm trial of weekly intravenous temsirolimus administration in men with chemorefractory mCRPC who had ≥ 5 circulating tumor cells (CTCs) at baseline. The primary end point was the change in CTCs at 8 weeks; secondary end points were composite progression-free survival (PFS) (excluding prostate-specific antigen [PSA]), PSA and radiographic response rates, safety, and survival. At PSA/CTC progression, an anti-androgen could be added while continuing temsirolimus.
RESULTS:
Eleven patients were accrued out of a planned 20; the trial was stopped prematurely because of lack of efficacy/feasibility. Median age was 61 years, with 55% African-Americans and 36% Caucasian patients. Median baseline PSA level was 390 ng/dL, median baseline number of CTCs was 14 cells; 50% of patients had pain, and 63% had undergone ≥ 2 previous chemotherapy regimens. Median CTC decline was 48% and 3 patients experienced decline in CTCs to < 5. However, 73% of men had a persistently unfavorable number of CTCs (≥ 5) and only 1 patient had a ≥ 30% PSA decline. Median PFS was 1.9 months (95% confidence interval [CI], 0.9-3.1) and median overall survival (OS) was 8.8 months (95% CI, 3.1-15.6). Toxicities included grade 4 hypophosphatemia and central nervous system (CNS) hemorrhage, and frequent grade 3 fatigue, anemia, stomatitis, hypokalemia, weakness, and hyperglycemia.
CONCLUSION:
Temsirolimus lacked sufficient clinical activity in men with mCRPC, despite transient CTC improvements in some men. Future studies should focus on combination approaches or novel PI3K pathway inhibitors.
Keywords
Castration-resistant; Circulating tumor cells; Epithelial-mesenchymal transition; Metastatic prostate cancer; mTOR; N-cadherin; Prostate-specific antigen; Temsirolimus
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