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2730388 
Journal Article 
Comparative study of the efficacy and tolerability of amlodipine and lisinopril in the treatment of essential hypertension 
Franchi, M; Di Perri, T 
1997 
Yes 
Clinical Drug Investigation
ISSN: 1173-2563 
IPA/98/1154092 
Drug Invest 
REF 13 
English 
IPA COPYRIGHT: ASHP An open, randomized, crossover study was conducted for 3 months to assess the efficacy and tolerability of 5-10 mg/day of amlodipine vs 10-20 mg/day of lisinopril in 20 patients, mean age 59 yr, with mild to moderate essential hypertension. Both drugs significantly reduced systolic and diastolic blood pressures compared with baseline, although the reduction observed with amlodipine was significantly greater than that observed with lisinopril (23.5 vs 16.5 mm Hg for sitting systolic blood pressure; 21.1 vs 13.8 mm Hg for sitting diastolic pressure). Thirty-five percent of patients treated with the lower dosage of amlodipine (5 mg/day) experienced adequate blood pressure control, whereas only 10% could be successfully controlled with the initial dosage of lisinopril (10 mg/day). All patients were successfully controlled with higher dosages. The findings suggested that amlodipine provides effective control of blood pressure in patients with mild to moderate hypertension.