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2731516 
Journal Article 
Studies on irritancy and stinging potential 
Laden, K 
1973 
0 
Journal of the Society of Cosmetic Chemists
ISSN: 0037-9832 
IPA/74/112095 
Soc 
REF 6 
385-393 
English 
IPA COPYRIGHT: ASHP Animal and human methods for evaluating the stinging potential of cosmetic formulations placed on the skin were devised. Using these tests, various materials were evaluated for stinging potential. In addition, the primary irritancy of some of these compositions was evaluated. The results indicate that stinging potential and primary irritancy are unrelated. It was also observed that no general conclusions could be drawn as to predicting the stinging potential of solutions of acidic materials by considering solely the hydrogen ion concentration, tonicity, or the nature of the anion. Compounds studied included carboxylic acids (citric, acetic, aconitic, tartaric, ascorbic, etc.) sulfonic acids, (hexane sulfonic acid) and di- and tricarboxylic acids.