Chemical properties-dissolution relationship. Part 4. Behavior in solution of the diclofenac N-(2-hydroxyethyl) pyrrolidine salt (DHEP) | Health & Environmental Research Online (HERO)

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HERO ID

2732453

Reference Type

Journal Article

Title

Chemical properties-dissolution relationship. Part 4. Behavior in solution of the diclofenac N-(2-hydroxyethyl) pyrrolidine salt (DHEP)

Author(s)

Fini, A; Fazio, G; Orienti, I; Zecchi, V; Rapaport, I

Year

1991

Is Peer Reviewed?

Journal

Pharmaceutica acta Helvetiae
ISSN: 0031-6865

Report Number

IPA/92/1007177

Volume

Acta Helv

Issue

REF 10

Page Numbers

201-203

Language

English

Abstract

IPA COPYRIGHT: ASHP The behavior in solution of diclofenac N-(2-hydroxyethyl) pyrrolidine (diclofenac hydroxyethylpyrrolidine), the salt formed by diclofenac and N-(2-hydroxyethyl) pyrrolidine, was examined. This salt was found to be more soluble and dissolved more rapidly than diclofenac sodium. Above 35 mM of the salt, the solutions showed unexpected solubilization ability toward sparingly soluble materials. Studies have shown this salt to give faster plasma levels than the sodium salt when administered orally.