Health & Environmental Research Online (HERO)


Print Feedback Export to File
2733092 
Journal Article 
Gamma sorbitol as a diluent in tablets 
Guyot-Hermann, AM; Leblanc, D; Draguet-Brughmans, M 
1985 
Yes 
Drug Development and Industrial Pharmacy
ISSN: 0363-9045
EISSN: 1520-5762 
IPA/86/682046 
Ind 
REF 14 
551-564 
English 
IPA COPYRIGHT: ASHP Technological and biopharmaceutical properties of direct compression aspirin and ascorbic acid tablets were evaluated, using gamma-sorbitol as the diluent. Compression properties, hardness, disintegration and dissolution and stability were studied. Sorbitol showed a better ratio of compression force to hardness and longer disintegration and dissolution times than tablets using lactose as diluent. Disintegrant choice was also evaluated, and Ac-Di-Sol (croscarmellose sodium) was found most suitable, especially upon storage at high humidity.