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2733298 
Technical Report 
Pharmacokinetics of factor VIII: appropriateness of the one compartment model for estimating clearance 
Matucci, M; Longo, G; Morfini, M; Vannini, S; Messori, A; Et al 
1983 
IPA/84/579157 
Prat 
REF 21 
306-311 
IPA COPYRIGHT: ASHP An evaluation of 12 previously reported plasma concentration-time curves and examination of the data from 17 hemophilia patients treated with factor VIII (antihemophilic factor) were used to determine the appropriateness of a one compartment pharmacokinetic model for fitting of data. Percentage error calculations for clearance estimates in the 2 data sets were 0.7 and 7.2%, respectively. It was concluded that dosage calculation based on the one compartment model is appropriate.