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2735342 
Journal Article 
Abstract 
Induction of tumors in nonhuman primates with various chemical carcinogens 
Adamson, RH; Correa, P; Dalgard, DW 
1974 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
29 
1 
93 
English 
WOS:A1974T653800051 
is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974
Various chemicals which are carcinogenic in rodents have been evaluated for their carcinogenic potential in non-human primates, primarily rhesus and cynomolgus monkeys. Among carcinogens evaluated were various polycyclic hydrocarbons, fluorenylacetamides, azo dyes, urethane, various nitroso compounds, aflatoxin Bi. cycasin and its aglycone and procarbazine. Liver tumors have been induced by ip and/or oral N-nitrosodiethylamine (DENA), 1-nitrosopiperidine, N-nitrosodipropylamine, aflatoxin B1 and cycasin. Leukemias and lymphomas have been induced following administration of procarbazine and squamous cell carcinoma of the oral cavity and esophagus has been induced by oral administration of methylnitrosourea. DENA is the most potent liver carcinogen thus far tested. After ip administration of DENA every other week to newborn rhesus monkeys, 100 % of the monkeys developed tumors within 10-15 months. All of the monkeys developed a significant elevation in alpha fetoprotein levels 3-6 months in advance of gross or histologic evidence of tumors. Thus the non-human primates are good models for evaluating potential carcinogens and for developing biological markers for detecting preneoplastic changes as well as frank neoplasia. 
Thirteenth Annual Meeting of the Society of Toxicology 
Washington, D.C. 
March 10–14, 1974