Health & Environmental Research Online (HERO)


Print Feedback Export to File
2738290 
Journal Article 
Review 
Adverse effects of growth hormone replacement therapy in children 
Souza, FM; Collett-Solberg, PF 
2011 
0 
Arquivos Brasileiros de Endocrinologia e Metabologia
ISSN: 0004-2730
EISSN: 1677-8487 
55 
8 
559-565 
English 
22218437 
WOS:000298885900009 
Human growth hormone (hGH) replacement therapy has been widely available for clinical purposes for more than fifty years. Starting in 1958, hGH was obtained from cadaveric pituitaries, but in 1985 the association between hGH therapy and Creutzfeldt-Jakob disease was reported. In the same year, the use of recombinant hGH (rhGH) was approved. Side effects of rhGH replacement therapy in children and adolescents include rash and pain at injection site, transient fever, prepubertal gynecomastia, arthralgia, edema, benign intracranial hypertension, insulin resistance, progression of scoliosis, and slipped capital femoral epiphysis. Since GH stimulates cell multiplication, development of neoplasms is a concern. We will review the side effects reported in all rhGH indications. 
Growth hormone; side effects; gynecomastia; intracranial hypertension; scoliosis; pediatrics; short stature