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2738650 
Journal Article 
Case-control study of estrogen replacement therapy and risk of cervical cancer 
Parazzini, F; La Vecchia, C; Negri, E; Franceschi, S; Bolis, G; Et al 
1997 
Yes 
British Medical Journal (International Edition)
ISSN: 0959-8146
EISSN: 0959-535X 
IPA/97/1132151 
Med 
REF 19 
85-88 
English 
IPA COPYRIGHT: ASHP A case-control study evaluating the association between the use of estrogen replacement therapy and the risk of cervical neoplasms was conducted among 645 women, ages 40-75 yr, who had a diagnosis of cervical cancer and 749 women, ages 40-75 yr, who served as unmatched controls; replacement therapy was not necessarily postmenopausal. Forty of the case patients versus 86 controls had ever used estrogens, and the corresponding multivariate odds ratio was 0.5. The odds ratios of cervical cancer decreased with duration of use, being 0.6 for less than 12 months' use and 0.5 for use for 12 months or more compared with never users. The protection tended to be somewhat stronger for women reporting first estrogen use before age 50 yr. The odds ratio was 0.9 for women who had taken estrogens within the past 10 yr and 0.4 for those who had taken them 10 or more yr previously. It was suggested that exogenous estrogens do not increase the risk of cervical cancer and may decrease the risk.