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2738664 
Journal Article 
Melanogenesis inhibitor from paper mulberry 
Jang, DI; Lee, BG; Jeon, CO; Jo, NS; Koh, JS; Et al 
1997 
0 
Cosmetics and Toiletries
ISSN: 0361-4387 
IPA/97/1126442 
Toiletries 
REF 10 
59-62 
IPA COPYRIGHT: ASHP 5-(3-(2,4-Dihydroxyphenyl)propyl)-3,4-bis(3-methyl-2-butenyl)-1,2-benzenediol, an inhibitor of tyrosinase, which is the key enzyme responsible for melanin formation, was isolated from the root bark of Broussonetia krazinoki x B. papyrifera (paper mulberry), and various in vitro and in vivo tests were performed to determine the compound's suitability for use in cosmetic skin whitening products. In vitro tests assessed the compound's inhibition of mushroom tyrosinase and free radical scavenging activity. In vivo tests investigated the depigmentation and skin sensitization of guinea pig skin, eye irritation of albino rabbits, and irritation and sensitization of human skin by the compound. The compound inhibited mushroom tyrosinase, scavenged free radicals, depigmented UV induced hyperpigmentation in guinea pigs, and did not irritate rabbit eyes. Also, the results of the safety tests on the skin of guinea pigs and human volunteers showed that this compound had no primary irritation and sensitization potential.