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2739582 
Journal Article 
Kinetics and mechanism of oxidation of dimetacrine, imipramine and phenothiazine drugs 
Gasco, MR; Carlotti, ME 
1977 
1 
Pharmaceutica acta Helvetiae
ISSN: 0031-6865 
IPA/79/354083 
Acta Helv 
REF 16 
296-301 
English 
IPA COPYRIGHT: ASHP The kinetics of oxidation of dimetacrine tartrate, imipramine hydrochloride and phenothiazines were investigated with a stopped flow colorimetric technique. The structure of the drugs, reduction of potentials and cation radical formation rates were correlated with pharmacodynamic properties. The classes of drugs investigated were: tranquilizers, dialkylaminoalkylphenothiazines with 3 carbon atoms in the side chain, e.g., promazine hydrochloride; antihistamines, dialkylaminoalkylphenothiazines with 2 carbon atoms in the side chain, e.g., promethazine hydrochloride; and the antidepressants dimetacrine and imipramine. The cation radical formation rates decreased, by increasing the reduction potentials in going from the drugs with antidepressant action to those with antihistamine properties and to the tranquilizers.