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HERO ID
2740158
Reference Type
Journal Article
Title
Pharmacological activity of an herbal extract: controlled clinical study
Author(s)
Borgia, M; Sepe, N; Borgia, R; Ori-Bellometti, M
Year
1981
Is Peer Reviewed?
Yes
Journal
Current Therapeutic Research
ISSN:
0011-393X
Report Number
IPA/81/453086
Volume
Ther
Issue
Sec 2
Page Numbers
525-536
Language
English
Abstract
IPA COPYRIGHT: ASHP A controlled clinical study was performed in 24 normal adult women to test the activity of an herbal extract (Amaro Medicanale Giuliani, containing rhubarb, gentian, boldo, and cascara) on salivary secretions; therapeutic activity was evaluated in a double-blind, double controlled trial (test preparation versus 2 pairs of its components and versus placebo) in 80 patients with mild GI tract disturbances. In the first study, salivary secretion was measured at 0-time and during 120 min after 6 different treatments administered according to a 6 x 6 Latin square design replied 4 times. The test preparation and its components induced a significant increase in salivary secretion over 30 min; like the active control (4% citric acid solution) and unlike placebo or placebo plus alcohol, no differences were observed at later measurements. In the second study, the efficacy of the test preparation as it affected loss of appetite, dyspepsia, constipation, and non-target symptoms was significantly better when compared with placebo and with the 2 different pairs of components. It was concluded that the test preparation appears to be an effective treatment for milder GI tract disturbances.
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