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2740638 
Journal Article 
Efficacy of topical tuaminoheptane combined with N-acetyl-cysteine in reducing nasal resistance: double blind rhinomanometric study versus xylometazoline and placebo 
Cogo, A; Chieffo, A; Farinatti, M; Ciaccia, A 
1996 
1 
Arzneimittel-Forschung
ISSN: 0004-4172
EISSN: 1616-7066 
IPA/97/1123092 
Forsch 
REF 14 
385-388 
IPA COPYRIGHT: ASHP A randomized double blind study comparing the decongestant effects of Rhinofluimucil, a nasal solution of tuaminoheptane sulfate and acetylcysteine (N-acetylcysteine), with those of xylometazoline and placebo was conducted using rhinomanometry in 18 healthy subjects (ages 20-47 yr) who received 2 instillations per nostril of 0.6 mg tuaminoheptane and 1.2 mg acetylcysteine, 1.2 mg xylometazoline, and placebo. After Rhinofluimucil and xylometazoline, nasal resistance significantly decreased from 0.3 to 0.19 Pa and from 0.31 to 0.17 Pa, respectively, and flow significantly increased. No effects were seen with placebo. Rhinofluimucil and xylometazoline showed rapid decongestant properties, with a significant decrease of resistance and increase of inspiratory flow. These effects were not seen with placebo. The decongestant effect was seen 5 min after instillation and remained constant up to 20 min without any rebound effect.