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2741054 
Technical Report 
Bioavailability of valproic acid in man from two Deprakine formulations 
Johannessen, SI; Storslett, H; Salvesen, B 
1978 
IPA/79/360083 
Nor 
REF 20 
159-172 
English 
IPA COPYRIGHT: ASHP A crossover bioavailability study of 2 valproate sodium (sodium di-n-propyl acetate; Deprakine; I) formulations, a tablet and an aqueous solution, in 5 healthy female volunteers, aged 23-32 yr, is described. Two tablets of I, 600 mg or 3.0 ml (600 mg) of the solution were swallowed with 200 ml of water. Serum concentration/time profiles are given. The experimental serum level/time data were fitted in with an open one compartment model, with first order absorption. Elimination kinetics and common pharmacokinetic parameters were evaluated through computer analysis. An average elimination half-life was found to be 13.9 hr and the average volume of distribution was 0.16 l/kg. Peak levels of 53.6 mug/ml were obtained after 1-3 hr for the solution and 2-3 hr for tablets. Degree of absorption from the solution was significantly better than that from the tablets.