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2741108 
Journal Article 
Comparative study of sodium starch glycolate as a direct compression disintegrant 
Fenyvesi, E; Balazs, A; Szalay, L; Saghi, P 
1991 
0 
Acta Pharmaceutica Hungarica
ISSN: 0001-6659 
IPA/92/995240 
Hung 
REF 9 
153-159 
IPA COPYRIGHT: ASHP The physical properties and effects of a preparation of sodium starch glycolate (SSG) were compared with those of other disintegrants in directly compressed tablet formulations containing cellulose microcrystalline (Avicel) as a carrier and furosemide as a model drug. SSG met the requirements of a good disintegrant. It was found to be superior to croscarmellose sodium (Ac-Di-Sol) and crospovidone (Polyplasdone XL) in all respects and equivalent or nearly equivalent to Primojel, another preparation of SSG. The stability of tablets during storage was highest in those containing the SSG preparations. Furosemide dissolution was improved slightly more by Primojel than by the new preparation of SSG.