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2742397 
Journal Article 
Azafrin from roots of Pedilanthus tithymaloides 
Upadhyay, RR; Hecker, E 
1974 
1 
Phytochemistry
ISSN: 0031-9422
EISSN: 1873-3700 
HEEP/75/02734 
OXF 
OXF 
752-753 
HEEP COPYRIGHT: BIOL ABS. To study the occurrence and distribution of irritants and cocarcinogens in plants, 1 kg of roots were Soxhleted with diverse solvents of increasing polarity and the irritation unit (IU) and median irritation doses (ID-50) were determined on the mouse. The dried roots do not contain irritant principles such as 12, 13-di- or 13-monesters of phorbol and related diterpenes derivatives, or cryptic irritants such as 12, 13, 20-triesters of phorbol and related diterpenes.