Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: systematic review | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

2742548

Reference Type

Journal Article

Title

Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: systematic review

Author(s)

De Craen, AJ; Di Giulio, G; Lampe-Schoenmaeckers, AJ; Kessels, AG; Kleijnen, J

Year

1996

Is Peer Reviewed?

Yes

Journal

British Medical Journal (International Edition)
ISSN: 0959-8146
EISSN: 0959-535X

Report Number

IPA/97/1113196

Volume

Med

Issue

REF 45

Page Numbers

321-325

Language

English

Abstract

IPA COPYRIGHT: ASHP A review and meta-analysis is presented of 24 clinical studies evaluating the efficacy and side effects of 400-1000 mg of acetaminophen (paracetamol) alone and in combination with 10-60 mg of codeine in pain therapy. Only the 21 trials that employed a single dose design could be combined for analysis of analgesic efficacy. Pooled efficacy results indicated that codeine added to acetaminophen provided a 5% increase in analgesia on the sum pain intensity difference. This effect was comparable to the difference in analgesic effect between codeine and placebo. The cumulative incidence of side effects with each treatment was comparable in the single dose trials. In the multidose studies a significantly higher proportion of side effects occurred with the acetaminophen-codeine preparations.