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2743503 
Journal Article 
Rifamycins as inhibitors of collagenase activity: their possible pharmacological role in collagen degradative diseases 
Di Giulio, A; Barracchini, A; Cellai, L; Martuccio, C; Pantaleoni, G; Et al 
1996 
Yes 
International Journal of Pharmaceutics
ISSN: 0378-5173
EISSN: 1873-3476 
IPA/98/1137310 
J 
REF 18 
27-35 
English 
IPA COPYRIGHT: ASHP The interactions between 6 natural or semi-synthetic rifamycins and bacterial collagenase were studied in vitro. The rifamycins produced a marked inhibition of enzyme activity, with a concentration causing half-maximal inhibition (IC-50) ranging from 13.1 to 20.7 muM. The inhibitory effect was reversible as demonstrated by restoration of enzymatic activity by dialysis.