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2744385 
Journal Article 
Controlled study in the treatment of osteoarthritis with diacetylrhein (Artrodar) 
Lingetti, M; D'Ambrosio, PL; Di Grezia, F; Sorrentino, P; Lingetti, E 
1982 
Yes 
Current Therapeutic Research
ISSN: 0011-393X 
IPA/83/500046 
Ther 
REF 4 
408-412 
English 
IPA COPYRIGHT: ASHP In a double blind study of 20 patients with osteoarthritis of the hip or knee, the efficacy of oral diacetylrhein (I; Artrodar; 1,8-diacetoxy-9,10-anthraquinone-3-carboxylic acid), 50-100 mg daily, was assessed. Clinical response was assessed in terms of symptomatic relief, functional change, and objective measurements. The drug was significantly effective both at the dose of 50 mg daily (first 4 wk) and 100 mg daily (further 8 wk), with a minimum of side effects. The results were classified as good or excellent in 85% of the patients treated.