US EPA

2745092 

Journal Article 

Pefloxacine mesilate- and ofloxacin-loaded polyethylcyanoacrylate nanoparticles: characterization of the colloidal drug carrier formulation 

Fresta, M; Puglisi, G; Giammona, G; Cavallaro, G; Furner, PM; Et al 

1995 

Yes 

Journal of Pharmaceutical Sciences
ISSN: 0022-3549
EISSN: 1520-6017 

IPA/96/1100257 

Pharm 

REF 55 

895-902 

English 

IPA COPYRIGHT: ASHP The influence of preparation conditions of polyethylcyanoacrylate (PECA) nanoparticles on pefloxacine mesilate (pefloxacin mesylate) and ofloxacin loading capacity, nanoparticle size, and mean polymer molecular weight (MW), as well as release profile and the in vitro antimicrobial effectiveness, were evaluated. The incorporation and adsorption methods used to load the drugs in PECA nanoparticles were both capable of influencing nanoparticle size, MW, release profile, and drug-polymer association. The incorporation method for the ofloxacin system achieved PECA nanoparticle suspensions with a mean size value 3 times higher than that obtained in the absence of drug. The MW values of pefloxacin loaded systems showed an enhancement in average MW values, whereas a reduction was observed for ofloxacin loaded systems. The adsorption method showed no difference in particle size, MW, and storage stability compared with nanoparticles prepared without drugs. Drug release from nanoparticles was biphasic for both preparation processes. Drug loaded nanoparticles showed an enhancement of antimicrobial activity against standard bacteria strains from 2- to 50-fold compared with free drugs.