Health & Environmental Research Online (HERO)


Print Feedback Export to File
2745632 
Technical Report 
Mutagenicity of dichlorvos and other structurally related pesticides in Salmonella and Steptomyces 
Carere, A; Ortali, VA; Cardamone, G; Morpurgo, G 
1978 
PESTAB/79/0379 
Biol 
2-3 
PESTAB. To determine whether the mutagenic properties of dichlorvos are due to the whole molecule or only part of it, dichlorvos and structurally related pesticides were tested on histidine (his) requiring strains of Salmonella typhimurium, and on Streptomyces coelicolor. Dichlorvos and trichlorphon, which possess dichlorovinyl side groups, were mutagenic in both Salmonella and Steptomyces. The five organophosphorus pesticides, azinphos methyl, fenchlorphos (ronnel), mevinphos, monocrophotos and methyl parathion are similar to dichlorvos but are devoid of the dichlorovinyl group. None of these five compounds increased spontaneous mutations in either genetic system. Three carbamates, di-allate, triallate and Vegadex (sulfallate), contain chloroallyl groups similar to the vinyl group. All three were weakly mutagenic in Streptomyces. Triallate and Vegadex are strong mutagens in Salmonella. The carbamates EPTC and noruron (norea) lack chloroallyl groups and were not mutagenic. The presence of vinyl chloride or allyl chloride appeared to be responsible for the induction of point mutations.