Renal prostaglandin E2 in nephrogenic diabetes insipidus: effects of inhibition of prostaglandin synthesis by indomethacin | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2746755

Reference Type

Journal Article

Title

Renal prostaglandin E2 in nephrogenic diabetes insipidus: effects of inhibition of prostaglandin synthesis by indomethacin

Author(s)

Usberti, M; Dechaux, M; Guillot, M; Seligmann, R; Pavlovitch, H; Et al

Year

1980

Is Peer Reviewed?

Yes

Journal

Journal of Pediatrics
ISSN: 0022-3476
EISSN: 1097-6833

Report Number

IPA/80/414192

Volume

Pediatr

Issue

REF 13

Page Numbers

1980

Language

English

Abstract

IPA COPYRIGHT: ASHP The effects of indomethacin (I) on diuresis and urinary prostaglandin E2 excretion were studied in 2 children aged 15 months and 2.6 yr with nephrogenic diabetes insipidus. I was given at a dose of 3 mg/kg/day in 3 doses for 3 days. In both patients, there was a significant decrease of diuresis. Urinary prostaglandin E2 was very high in one patient and slightly elevated in the other. Urinary cyclic AMP values were abnormal in both patients.