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2747545 
Journal Article 
Study of the swelling of tablet excipients using video recording 
Wan, LS; Prasad, KP 
1990 
Yes 
Drug Development and Industrial Pharmacy
ISSN: 0363-9045
EISSN: 1520-5762 
IPA/90/917258 
Ind 
REF 11 
921-933 
English 
IPA COPYRIGHT: ASHP A video recording technique was used to study microscopically the swelling characteristics of the following individual tablet disintegrant particles in water: cross-linked sodium carboxymethylcellulose (croscarmellose sodium; Ac-Di-Sol; I), low substituted sodium carboxymethylcellulose (Nymcel ZSB-10; II), Nymcel ZSD-16 (III), and hydrated microcrystalline cellulose (Avicel PH-101; IV). Feret's diameter, projected area and dimensionless shape factors such as elongation ratio, bulkiness factor and surface factor of various particle profiles were determined. Hydrated particles of I, II and III had high Feret's diameter and projected areas. Swelling in their case was due to the hydration of macromolecules. Hydrated IV particles had a narrow distribution of both Feret's diameter and projected area. The low degree of swelling in these particles was due to entry of water into particle pores. The order for increase in projected area diameter after hydration was I|GT|GT/III|GT/IV./DEFICIENCY