Flecainide half-life prolongaton in 2 patients with congestive heart failure and complex ventricular arrhythmias | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2748736

Reference Type

Journal Article

Title

Flecainide half-life prolongaton in 2 patients with congestive heart failure and complex ventricular arrhythmias

Author(s)

Cavalli, A; Maggioni, AP; Marchi, S; Volpi, A; Latini, R

Year

1988

Is Peer Reviewed?

Yes

Journal

Clinical Pharmacokinetics
ISSN: 0312-5963
EISSN: 03125963

Report Number

IPA/89/822267

Volume

Pharmacokinet

Issue

REF 6

Page Numbers

187-188

Language

English

Abstract

IPA COPYRIGHT: ASHP The case histories of 2 patients (aged 60 yr and 73 yr) treated with long term 100 mg flecainide (I) twice daily for congestive heart failure and ventricular arrhythmias were presented due to an unexpected prolongation of I plasma half-life and worsening of the left ventricular function. Due to the increase in plasma half-life, it was suggested that a reduction in dosage be considered in individual congestive heart failure patients treated with long term I.