US EPA

2749905 

Journal Article 

Chemical Exposures, Medical History, and Risk of Squamous and Basal Cell Carcinoma of the Skin 

Gallagher, RP; Bajdik, CD; Fincham, S; Hill, GB; Keefe, AR; Coldman, A; Mclean, DI 

1996 

Yes 

Cancer Epidemiology
ISSN: 1877-7821 

NIOSH/00235152 

5 

6 

419-424 

English 

8781736 

WOS:A1996UQ20800002 

A study was conducted examining risk factors associated with the development of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Genetic, occupational, and environmental risk factors were evaluated in 180 SCC and 226 BCC cases and in 406 matched referents. History of previous skin cancer in parents and nondiagnostic X-ray exposure were risk factors for both SCC and BCC; rheumatoid arthritis was a risk factor for SCC. No clear occupational associations for either SCC or BCC were identified. An increased risk of BCC appeared to be associated with exposure to asbestos (1332214) or fiberglass dust and luminous paint, whereas risk of SCC was increased in those exposed to insecticides, herbicides, fungicides or seed treatments, grain or coal dust, and petroleum products, grease, and diesel fumes. Dose related associations between SCC and exposure to insecticides, herbicides, fungicides, and seed treatments continued to be significant following adjustment for sun exposure. Dose response relationships were also identified between SCC and exposure to petroleum products, grease, diesel fumes, and coal dust. The authors conclude that nonsolar factors appear to contribute to risk of SCC and BCC. 

DCN-235577; Risk factors; Skin cancer; Occupational exposure; Environmental exposure; Asbestos dust; Agricultural chemicals; Toxic effects; Petroleum products; Dose response; 1332-21-4