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Technical Report 
Pediatric clinical phenotype variant of lysosomal acid lipase deficiency responsive to an HMG CoA reductase inhibitor (simvastatin) plus cholestyramine 
Leone, L; Antonicelli, R; Giunta, S; Paciaroni, E; Ippoliti, PF 
REF 14 
IPA COPYRIGHT: ASHP The case of a 4-yr-old boy with genetically transmitted lysosomal acid lipase deficiency (cholesterol ester storage disease) is presented. The patient was put on a hypolipidic diet, cholestyramine resin (0.22 g/kg twice daily), simvastatin (0.28 mg/kg/day), lipophilic vitamins, and folic acid. After 3 yr of treatment, a significant improvement in clinical and laboratory data was achieved.