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2750853 
Journal Article 
Nephrotoxicity of 2-bromo(cystein-S-yl)hydroquinone and 2-bromo-(N-acetyl-L-cystein-S-yl)hydroquinone thioethers 
Monks, TJ; Jones, TW; Hill, BA; Lau, SS 
1991 
1 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
BIOSIS/92/04543 
111 
2 
279-298 
English 
BIOSIS COPYRIGHT: BIOL ABS. The in vivo toxicity of isomeric cystein-S-yl and N-acetylcystein-S-yl conjugates of 2-bromohydroquinone was determined in male Sprague-Dawley rats. 2-Bromo-(dicystein-S-yl)hydroquinone (2-Br-(diCYS)H) and 2-bromo-(di-N-acetyl-L-cystein-S-yl)hydroquinone (2-Br-(diNAC)HQ) were considerably more nephrotoxic than their corresponding monosubstituted thioethers and 2-Br-(diCYS)HQ was more nephrotoxic than 2-Br-(diNAC)HQ. 2-Br-(diCYS)HQ caused elevations in blood urea nitrogen (BUN) concentrations and increases in the urinary excretion of glucose, lactate dehydrogenase (LDH), and gamma-glutamyl transpeptidase (gamma-GT) at a dose of 25 mumol/kg (iv). In contrast, 2-Br-(diNAC)HQ caused significant elevations in BUN at 100 mumol/kg and glucosuria and enzymuria at 50 mumol/kg. 2-Br-3-(CYS)HQ and 2-Br-5 and 6-(CYS)HQ caused increases in the biochemical indices of nephrotoxicity at doses between 50 and 150 mumol/kg whereas 2-Br-5-(NAC)HQ and 2-Br-6-(NAC)HQ required doses of 150-200 mum