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2754046 
Journal Article 
Cimetidine induced impotence and breast changes in patients with gastric hypersecretory states 
Jensen, RT; Collen, MJ; Pandol, SJ; Allende, HD; Raufman, JP; Et al 
1983 
1 
New England Journal of Medicine
ISSN: 0028-4793
EISSN: 1533-4406 
IPA/84/548020 
Engl 
REF 29 
883-887 
English 
6835285 
IPA COPYRIGHT: ASHP To determine whether cimetidine (Tagamet; I) causes important antiandrogen side effects, 22 male patients (aged 43-64 yr) with gastric hypersecretory states given high dose I were studied. Patients who continued to report impotence or breast changes or both for longer than 2 months while taking I were switched to ranitidine (II), had their dose of I reduced, or had I discontinued after surgical resection of a gastrinoma. The results showed that impotence, breast tenderness, or gynecomastia developed in 50% of the patients, and that these side effects disappeared when I was replaced by II. It was concluded that because of its lack of antiandrogen side effects and its efficacy of inhibiting gastric acid secretion, II appears to be a preferable antagonist of histamine H2 receptors in the treatment of men with gastric hypersecretory states.