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2759075 
Journal Article 
Neural maturation of breastfed and formula-fed infants 
Khedr, EM; Farghaly, WM; Amry, S; Osman, AA 
2004 
Yes 
Acta Paediatrica
ISSN: 0803-5253
EISSN: 1651-2227 
93 
6 
734-738 
English 
15244219 
BACKGROUND: Human milk provides infants with a full complement of all polyunsaturated fatty acids, including docosahexaenoic acid (DHA) and arachidonic acid (AA). Formula milks only contain the precursors of DHA, AA and linoleic acid, and hence formula-fed infants must synthesize their own DHA and AA.

AIM: To evaluate the effect of feeding--whether breastfeeding or formula-feeding--in early infancy upon subsequent neurodevelopment and achievement of optimum brain function.

SUBJECTS AND METHODS: The study included 53 normal, healthy infants (30 exclusively breastfed infants and 23 exclusively formula-fed infants) at the age of 1 y (+/-1 mo). Each infant was subjected to a full physical and neurological examination together with neurophysiological studies including flash visual evoked potential (FVEP), brainstem auditory evoked potential (BAEP) and somatosensory evoked potential (SSEP).

RESULTS: There was significant prolongation of P100 wave latency of FVEP in formula-fed infants, together with significant prolongation of absolute latency of waves I, III and V of BAEP in formula-fed infants compared with breastfed infants. There was significant prolongation in inter-peak latencies between cortical and Erb's components in formula-fed infants compared with breastfed infants.

CONCLUSION: We can conclude that VEP, BAEP and SSEP are more mature in breastfed infants relative to formula-fed infants at 1 y of age, and thus breast milk helps earlier development and maturation of some aspects of the nervous system than milk formulas.