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2771609 
Journal Article 
Reproductive and neurobehavioral effects of Allura Red AC administered to mice in the diet 
Tanaka, T 
1994 
Yes 
Toxicology
ISSN: 0300-483X
EISSN: 1879-3185 
92 
1-3 
169-177 
English 
7940558 
WOS:A1994PK03500013 
The color additive, Allura Red AC, was given in the diet to provide levels of 0.42, 0.84, and 1.68% (control, 0%), from 5 weeks of age of the F0 generation to 9 weeks of age of the F1 generation in mice, and selected reproductive and neurobehavioral parameters were measured. There were few adverse effects of Allura Red AC on either litter size or weight, and ratio of male to female was significantly reduced in the lowest dosed group. Average body weight of offspring during the lactation period was significantly increased in the lower dosed groups of each sex. As regards the neurobehavioral parameters, no adverse effect was observed in the behavioral development during lactation period. There were few adverse effects of Allura Red AC on either movement activity or maze learning in F1 generation mice, compared with controls in each sex. The dose levels of Allura Red AC in the present study (approximately 86-1430 times greater than human ADI) produced few adverse effects in reproductive and neurobehavioral parameters in mice. 
Allura Red AC; FD&C Red No. 40; Reproductive toxicity; Behavioral development; Movement activity; Maze learning; Mice