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2775195 
Journal Article 
Dietary sources and background levels of hippuric acid in urine: Comparison of philippine and japanese levels 
Villanueva, MBG; Jonai, H; Kanno, S; Takeuchi, Y 
1994 
Yes 
Industrial Health
ISSN: 0019-8366
EISSN: 1880-8026 
BIOSIS/95/34280 
32 
4 
239-246 
English 
7591853 
WOS:A1994RT02400005 
A study of dietary sources and background levels of hippuric-acid (495692) in Filipino and Japanese subjects was conducted. Forty four food items including six varieties of soy sauce, 30 of fruit juice, and eight of soft drinks manufactured and consumed in the Philippines, and 31 items including five soy sauces, 21 fruit juices, and five soft drink varieties manufactured and consumed in Japan were analyzed for sodium-benzoate by high performance liquid chromatography (HPLC). Urine samples were collected from 34 Japanese and 43 Filipino males not occupationally exposed to toluene (108883) and analyzed for hippuric-acid by HPLC. Thirty one (70%) of the Filipino food items contained detectable amounts of sodium-benzoate. Of these, 19 were fruit juices, six soft drinks, and six were soy sauces. The sodium-benzoate concentrations ranged from 20 to 3,250 micrograms per milliliter (microg/ml). The highest concentrations were found in the soy sauces. Only eight Japanese food products (26%), three soft drinks and five types of soy sauce, contained sodium-benzoate. The concentrations varied from less than 50 to 200microg/ml. The highest concentrations were found in the soft drinks. Hippuric-acid concentrations excreted by the Filipino and Japanese subjects ranged from 0.01 to 0.80 and 0.02 to 0.43 gram per gram creatinine (g/g), respectively. The respective geometric means were 0.11 and 0.09g/g. The difference in the means was not statistically significant. The authors conclude that more of the Filipino food products contain sodium-benzoate and at higher concentrations than the Japanese food items. This suggests that Filipinos consume more sodium-benzoate. This is not borne out by the urine hippuric-acid concentration data. The lack of a correlation between presumed sodium-benzoate consumption and hippuric-acid excretion could reflect differences in socioeconomic characteristics or sodium-benzoate metabolism in the two populations. 
SODIUM BENZOATE; BACKGROUND HIPPURIC ACID; FILIPINO; JAPANESE