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2775326 
Journal Article 
Pharmacokinetics of intravenous caffeine in critically ill patients 
Sanchez-Alcaraz, A; Ibanez, P; Sangrador, G 
1991 
Yes 
Journal of Clinical Pharmacy and Therapeutics
ISSN: 0269-4727
EISSN: 1365-2710 
IPA/92/995436 
Clin 
REF 7 
285-289 
English 
1939407 
WOS:A1991GC34100009 
IPA COPYRIGHT: ASHP The pharmacokinetics of caffeine were studied in 20 critically ill patients (aged 18-83 yr) who received a single intravenous infusion of 3 mg/kg caffeine sodium benzoate to measure liver function. Caffeine pharmacokinetics fitted an open one-compartment model. The mean value for half-life was 0.46 h, volume of distribution was 0.55 l/kg, and plasma clearance was 0.85 ml/min/kg. Compared with pharmacokinetics previously reported in healthy subjects, plasma clearance of caffeine was reduced and plasma half-life was prolonged, whereas volume of distribution remained unchanged in these patients.