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2775367 
Journal Article 
Stability of propranolol hydrochloride suspension and solution compounded from injection or tablets 
Gupta, VD; Stewart, KR 
1987 
Yes 
American Journal of Hospital Pharmacy
ISSN: 0002-9289 
IPA/87/729106 
J 
REF 3 
360-361 
English 
IPA COPYRIGHT: ASHP The stability of an oral solution or suspension of propranolol hydrochloride (Inderal; I), prepared from either I injection or oral tablet, was studied. The suspension was prepared by crushing 6 tablets of I, 20 mg each, and mixing with 240 ml of a simple syrup containing sucrose (II), 600 mg/ml. The solution was prepared by diluting 50 ml of I injection, 1 mg/ml with the syrup to yield a total volume of 100 ml. After storage at 25DGC, each formulation was assayed at intervals up to 238 days by high performance liquid chromatography. The results indicate that both preparations retained almost original potency after 238 days of storage at room temperature. The clarity of the solutions did not change, and changes in the pH values were negligible. There were no visible signs of any fungus growth; this was expected since the syrup contained sodium benzoate as the preservative. It was concluded that oral liquid dosage forms of I can be prepared by suspending triturated tablets in or mixing an injectable preparation of the drug with a simple syrup of II, 600 mg/ml.