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2775721 
Journal Article 
Geometric approach for zero-order release of drugs dispersed in an inert matrix 
Bayomi, MA 
1994 
1 
Pharmaceutical Research
ISSN: 0724-8741
EISSN: 1573-904X 
IPA/95/1075235 
Res 
REF 10 
914-916 
English 
7937535 
WOS:A1994NR16600023 
IPA COPYRIGHT: ASHP To design a suitable geometry in a fashion that would compensate for the increasing diffusional distance across the drug-depleted zone to achieve a zero-order release, release kinetics for the proposed geometry of benzoic acid dispersed in the fatty base Witepsol H-15 was studied; release kinetics from benzoic acid from a slab (cylindrical shape with identical cross sectional area throughout the matrix was considered as a slab in this study) were also studied. The release of benzoic acid from 2 parabolic matrices of different K values showed that within 9 days, matrix geometries of K = 0.6 and 1.0 provided 24 and 35% drug release, respectively. Release kinetics from both parabolic geometries closely approximated zero-order. Release kinetics from slab geometry was far from zero-order. The parabolic devices yielded linear release profiles and the smaller K better approximated zero-order release as compared to the higher K value. 
ZERO-ORDER RELEASE; PARABOLIC GEOMETRY; SUSPENSION MATRIX; BENZOIC ACID