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2775998 
Journal Article 
Synthesis and evaluation of new linear azo-polymers for colonic targeting 
Van Den Mooter, G; Offinga, M; Kalala, W; Samyn, C; Kinget, R 
1995 
1 
STP Pharma Sciences
ISSN: 1157-1489 
IPA/96/1089273 
T 
REF 17 
36-40 
WOS:A1995QE37000005 
IPA COPYRIGHT: ASHP Copolymers of 4-(4-((6-hydroxyhexyl)oxy)phenylazo)benzoic acid and 16-hydroxyhexadecanoic acid were synthesized, and the degradation of the azo-polymers was examined in rat cecal content in vitro to determine their potential for colonic targeting. The polymers could be degraded by rat bacterial azo-reductase to polymers with lower molecular weight. The degradation of the polymers was most likely attributable to a reduction and split of the azo-bonds by bacterial azo-reductase. As a function of the incubation time, the UV absorption spectra at 360 nm, due to the presence of azo-bonds, decreased significantly. It was concluded that the azo-polymers may offer the possibility of delivery of drugs specifically to the colon. 
COLON TARGETING; AZO-POLYMERS; AZO-REDUCTASE; BIODEGRADABLE POLYMERS; VISCOSITY MEASUREMENTS; UV ABSORPTION SPECTROMETRY; POLYCONDENSATION POLYMERIZATION