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2778121 
Journal Article 
Evaluation of the mutagenicity of an N-nitroso contaminant of the sunscreen padimate O: N-nitroso-N-methyl-p-aminobenzoic acid, 2-ethylhexyl ester (NPABO) 
Dunkel, VC; San R, HC; Harbell, JW; Seifried, HE; Cameron, TP 
1992 
Yes 
Environmental and Molecular Mutagenesis
ISSN: 0893-6692
EISSN: 1098-2280 
20 
3 
188-198 
English 
1396609 
WOS:A1992JT90300006 
BIOSIS COPYRIGHT: BIOL ABS. The nitrosamine contaminant, N-nitroso-N-methyl-p-aminobenzoic acid, 2-ethylhexyl ester (NPABAO), of the major sunscreen ingredient Padimate O (4-N,N'-dimethylamino-benzoic acid, 2-ethylhexyl ester) was synthesized and tested for mutagenicity in the Salmonella typhimurium and mouse lymphoma L5178Y TK+/-assays. In contrast to the previously reported positive responses in S. typhimurium tester strains TA100 and TA1535 (Loeppky et al., 1991), there were no increases in the number of revertants with strains TA98, TA100, TA1535, and TA1538 in either the Salmonella plate incorporation (Ames et al., 1975) or preincubation (Yahagi et al., 1977) assays. Additional testing with salmonella, following the modified preincubation procedure (Rogan, 1990) that gave the initial positive response, was also negative. Data from the mouse lymphoma assays were also uniformly negative. During synthesis of NPABAO, small amounts of 4-N,N'-dimethylamino-3-nitrobenzic acid, 2-ethylhexyl ester (DM 
SALMONELLA; MOUSE LYMPHOMA; MUTAGENICITY; SUNSCREENS; NITROSAMINE