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2779991 
Book/Book Chapter 
1,1,2-Trichloro-1,2,2-trifluoroethane 
American Conference of Governmental Industrial Hygienists :: ACGIH 
2001 
American Conference of Governmental Industrial Hygienists 
Cincinnati, OH 
Documentation of the threshold limit values and biological exposure indices 
English 
is a chapter of 594530 Documentation of the threshold limit values and biological exposure indices
A TLV-TWA of 1000 ppm (7670 mg/m3) and a TLV-STEL of 1250 ppm (9590 mg/m3) are recommended for occupational exposure to 1,1,2-trichloro-1,2,2-trifluoroethane (FC-113) to minimize the potential, associated with exposure at extremely high concentrations, of narcosis, asphyxia, and cardiac sensitization and arrhythmia. Data from the exposure of human volunteers to CFC-113 indicate that the threshold concentration for impairment of human psychomotor performance, described as loss of ability to concentrate and mild lethargy, is about 2500 ppm. Although nasal tumors were found in rodents exposed for 2 years to CFC-113, they were of various morphological types and the incidences were not dose-related. Accordingly, an A4, Not Classifiable as a Human Carcinogen, notation is considered appropriate for CFC-113. Sufficient data were not available to recommend Skin or SEN notations. 
7th 
9781882417438