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2791491 
Journal Article 
Investigation of sorbic acid volatile degradation products in pharmaceutical formulations using static headspace gas chromatography 
Yarramraju, S; Akurathi, V; Wolfs, K; Van Schepdael, Ann; Hoogmartens, Jos; Adams, E 
2007 
Yes 
Journal of Pharmaceutical and Biomedical Analysis
ISSN: 0731-7085
EISSN: 1873-264X 
44 
2 
456-463 
English 
17306494 
WOS:000247765400017 
An analytical method that allows simultaneous analysis of sorbic acid and its degradation products was developed using static headspace gas chromatography (HS-GC). AT-Aquawax-DA, the capillary column used, showed good selectivity and separation towards sorbic acid and its degradation products. Sorbic acid degradation was investigated in both acidic and aqueous media at room and elevated temperatures. In total 12 sorbic acid degradation products were found, 8 of which could be characterized. The method was investigated for its accuracy towards estimation of degradation products. Using the HS-GC method different batches of pharmaceutical preparations such as cold cream, cetomacrogol cream and vaseline were investigated for sorbic acid degradation products which were estimated by applying the standard addition method. Acetaldehyde was found to be the major degradation product. The other identified degradation products were: acetone; 2-methylfuran; crotonaldehyde; alfa-angelicalactone; 2-acetyl, 5-methylfuran; toluene and 2,5-dimethylfuran. Both mass spectrometeric (MS) and flame ionization detection (FID) were used. The qualitative investigation was done on HS-GC-MS and the quantitative work on HS-GC-FID. 
sothic acid; degradation; cold cream; cetomacrogol cream; vaseline; GC