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HERO ID
2792843
Reference Type
Journal Article
Title
Bioactive Bromophycolides R-U from the Fijian Red Alga Callophycus serratus
Author(s)
Lin, AnS; Stout, EP; Prudhomme, J; Le Roch, K; Fairchild, CR; Franzblau, SG; Aalbersberg, W; Hay, ME; Kubanek, J
Year
2010
Is Peer Reviewed?
Yes
Journal
Journal of Natural Products
ISSN:
0163-3864
EISSN:
1520-6025
Volume
73
Issue
2
Page Numbers
275-278
Language
English
PMID
20141173
DOI
10.1021/np900686w
Web of Science Id
WOS:000274803600038
Abstract
Four new bromophycolides, R-U (1-4), were isolated from the Fijian red alga Callophycus serratus and were identified by 1D and 2D NMR and mass spectroscopic analyses. These compounds expand the known structural variety of diterpene-benzoate macrolides and exhibited modest cytotoxicity toward selected human cancer cell lines. Bromophycolide S (2) also showed submicromolar activity against the human malaria parasite Plasmodium falciparum.
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