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2794223 
Journal Article 
PLASMA ESTRADIOL-17-BETA CONCENTRATIONS IN THE COW DURING INDUCED ESTRUS AND AFTER INJECTION OF ESTRADIOL-17-BETA BENZOATE AND ESTRADIOL-17-BETA CYPIONATE - A PRELIMINARY-STUDY 
Vynckier, L; Debackere, M; Dekruif, A; Coryn, M 
1990 
1 
Journal of Veterinary Pharmacology and Therapeutics
ISSN: 0140-7783
EISSN: 1365-2885 
13 
1 
36-42 
English 
2319634 
WOS:A1990CR51900006 
Plasma estradiol-17 beta concentrations were investigated in cows during induced estrus and after an intramuscular injection of 10 mg of estradiol-17 beta benzoate and estradiol-17 beta cypionate to determine a withdrawal period for both preparations. After the estradiol-17 beta benzoate injection, the plasma estradiol-17 beta concentration was higher than the physiological maximum of 24 pg/ml obtained during induced estrus for a period of 114 +/- 10 h (mean +/- SEM). For estradiol-17 beta cypionate the corresponding value was 170 +/- 17 h (mean +/- SEM). A withdrawal period of 7 days for the benzoate ester and of 10 days for estradiol-17 beta cypionate is therefore proposed. These results were confirmed by biopsies taken at the injection site 8 and 15 days after the injection of estradiol-17 beta benzoate and estradiol-17 beta cypionate, respectively. In these biopsies no residues of estradiol-17 beta nor of its esters could be detected.