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2794785 
Journal Article 
EFFECTS OF PAF-ANTAGONISTS IN MOUSE EAR EDEMA INDUCED BY SEVERAL INFLAMMATORY AGENTS 
Merlos, M; Gomez, LA; Giral, M; Vericat, ML; Garciarafanell, J; Forn, J 
1991 
Yes 
British Journal of Pharmacology
ISSN: 0007-1188
EISSN: 1476-5381 
104 
4 
990-994 
English 
1810607 
WOS:A1991GT19000036 
1. Several platelet activating factor (PAF)-antagonists of different chemical structures were tested in the arachidonic acid-, tetradecanoylphorbol acetate-, dithranol-, and benzoic acid-induced mouse ear oedema models. 2. Topical application of UR-10324, UR-11353, CV-6209 and WEB-2086 markedly inhibited ear oedema induced by the four irritants tested, mimicking the profile obtained with dexamethasone. YM-461 was highly effective only in the dithranol-induced ear oedema, while BN-52021 failed to inhibit ear oedema in all models tested. 3. Leukocyte recruitment into the inflamed ears was prevented by PAF-antagonists, as measured by myeloperoxidase activity in the supernatants of ear homogenates. 4. A relationship between PAF-antagonist and anti-inflammatory activities was found in some cases, but other mechanisms cannot be excluded to explain the topical anti-inflammatory effect of these compounds. 5. Our results suggest that topical formulations containing PAF-antagonists could be useful in the treatment of some inflammatory skin diseases and provide evidence on the involvement of PAF in these inflammatory processes. 
PAF-ANTAGONISTS; MOUSE EAR EDEMA; ARACHIDONIC ACID; PHORBOL ESTERS; DITHRANOL; BENZOIC ACID; MYELOPEROXIDASE