Health & Environmental Research Online (HERO)


Print Feedback Export to File
2797082 
Journal Article 
Effect of aromatic hydrotropes on the solubility of oxamniquine .2. Effect of nicotinamide and sodium salts of benzoic, naphthoic, nicotinic and isonicotinic acids 
Ammar, HO; Khalil, RM 
1996 
Yes 
Die Pharmazie
ISSN: 0031-7144 
51 
7 
490-493 
English 
WOS:A1996UY77100008 
The effect of nicotinamide and sodium benzoate, naphthoate, nicotinate as well as isonicotinate on the solubility of oxamniquine in water was investigated. The investigated hydrotropes were found to increase the solubility of oxamniquine. Replacement of the benzene ring by a naphthalene or pyridine ring enhances solubilization. Molecular interaction of oxamniquine with these solubilizers were depicted by differential ultraviolet spectrophotometric measurements. Applying the continuous variation method revealed formation of 1:1 complexes of oxamniquine with sodium naphthoate, sodium isonicotinate and nicotinamide and 1:2 complexes with sodium nicotinate and sodium benzoate. The stability constant of the formed complexes was determined spectrophotometrically. Oxamniquine-sodium naphthoate complex was found to be the must stable complex, while the nicotinamide complex is the least stable one. An apparent correlation seems to exist between the solubilizing power or hydrotropes and the stability constant of their respective complex. except in case of sodium benzoate. Calculating the amounts of drug solubilized in free as well as in complexed forms in presence of the investigated hydrotopes revealed that solubilization of the drug by sodium benzoate. sodium naphthoate and nicotinamide is entirely due to complex-formation. On the other hand, solubilization of the drug by sodium nicotinate and sodium isonicotinate seems to be due to two factors, namely, complex-formation as well as the salting-in effect of the hydrotope.