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2798975 
Journal Article 
Benzyl chloroformate (CbzCl) synthesis using carbon monoxide as a carbonyl source 
Mizuno, T; Takahashi, J; Ogawa, A 
2002 
1 
Tetrahedron
ISSN: 0040-4020 
58 
50 
10011-10015 
English 
WOS:000179567300012 
A novel non-phosgene synthetic method for benzyl chloroformate (CbzCl) was established. S-Methyl O-benzyl carbonothioates were prepared by the carbonylation of benzyl alcohols with carbon monoxide and sulfur (or carbonyl sulfide) in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) followed by esterification using methyl iodide in good yields. Then, CbzCl derivatives were successfully synthesized by the chlorination of S-methyl O-benzyl carbonothioates using sulfuryl chloride in excellent yields. © 2002 Elsevier Science Ltd. All rights reserved. 
benzyl chloroformate; carbobenzoxy chloride; carbon monoxide; sulfur; carbonyl sulfide; carbonylation