Health & Environmental Research Online (HERO)


Print Feedback Export to File
2798976 
Journal Article 
Non-phosgene synthesis of benzyl chloroformate (CbzCl) 
Mizuno, T; Takahashi, J; Ogawa, A 
2002 
1 
Tetrahedron Letters
ISSN: 0040-4039
EISSN: 1873-3581 
43 
43 
7765-7767 
English 
WOS:000178534000027 
A novel synthetic method for benzyl chloroformate (CbzCl) using carbon monoxide or carbonyl sulfide as a carbonyl source was established. Benzyl chloroformate was successfully synthesized by the chlorination using sulfuryl chloride of S-methyl O-benzyl carbonothioate, which was prepared by the carbonylation of benzyl alcohol with carbon monoxide and sulfur (or carbonyl sulfide) in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) followed by esterification using methyl iodide. © 2002 Elsevier Science Ltd. All rights reserved. 
benzyl chloroformate; carbobenzoxy chloride; carbon monoxide; sulfur; carbonyl sulfide; carbonylation